853-71-4

Upstream product

• 1258-28-2 2,4,6-Triphenyl-4-<4-methoxy-benzyl>-4H-pyran 
• 19938-96-6 1-phenyl-1-(2-amino-5-methoxyphenyl)ethylene 
• 536-74-3 phenylacetylene 
• 133349-85-6 1-(4''-methoxybenzyl)-1H-benzo[d][1.2.3]triazole 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 1259-12-7 1,3,5-Triphenyl-3-(4-methoxy-phenyl)-pentandion-(1,5) 

Relevant academic research and scientific papers

Radical Addition/Cyclization Reaction of 2-Vinylanilines with Alkynes: Synthesis of Naphthalenes via Electron Catalysis

A cascade radical addition/cyclization reaction of 2-vinylanilines with alkynes for the synthesis of biologically important naphthalene derivatives is reported. In this transformation, the in-situ-formed diazonium salts from 2-vinylanilines served as efficient aryl radical precursors and the reaction was run under metal-free conditions.

Benzotriazole-Assisted Aromatic Ring Annulation: Efficient and General Syntheses of Polysubstituted Naphthalenes and Phenanthrenes

(Benzotriazol-1-ylmethyl)benzenes and -naphthalenes 1a-f, easily accessible from benzyl bromides and benzotriazole, readily undergo lithiation and subsequent 1,4-addition to α,β-unsaturated aldehydes and ketones. Intramolecular cyclization of the products, induced by acetic acid-hydrobromic acid or polyphosphoric acid (PPA), followed by simultaneous dehydration and debenzotriazolylation furnishes a wide range of polysubstituted naphthalenes 7a-f and of phenanthrenes 9 and 11 in moderate to good yields in one-pot procedures. If compounds 1 are first lithiated and reacted with electrophiles, the resulting alkylation products undergo similar annulation reactions with α,β-unsaturated carbonyl compounds to provide the more highly substituted naphthalenes 6a,b and phenanthrenes 10a,b in moderate overall yields.