85303-93-1

Usage

InChI:InChI=1/C17H17N3O/c1-11-7-8-12(2)15(9-11)17-18-16(19-20-17)13-5-4-6-14(10-13)21-3/h4-10H,1-3H3,(H,18,19,20)

Upstream product

• 22328-43-4 2,5-dimethylbenzoyl chloride 
• 610-72-0 2,5-dimethylbenzoic acid 
• 892020-32-5 N'-(2,5-Dimethyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester 
• 85304-04-7 2,5-Dimethyl-benzoic acid hydrazide 

Relevant academic research and scientific papers

A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles

A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.