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Usage

Uses

Used in Fragrance Industry:
2-hexyl-2-adamantanol is used as a fragrance ingredient in perfumes and personal care products for its ability to impart a pleasant odor and enhance the overall scent profile of the products it is used in.
Used in Pharmaceutical Industry:
2-hexyl-2-adamantanol may have potential uses in pharmaceutical applications due to its unique structure and potential biological activity, although specific applications are not detailed in the provided materials.
Used in Agricultural Industry:
2-hexyl-2-adamantanol may also have potential uses in agricultural applications, likely due to its unique structure and potential interactions with biological systems, although specific uses are not detailed in the provided materials.
Overall, 2-hexyl-2-adamantanol's diverse potential uses across various industries highlight its versatility and the value of its unique molecular structure in creating and enhancing products.

Upstream product

• 700-58-3 2-Adamantanone 
• 21369-64-2 n-hexyllithium 

Relevant academic research and scientific papers

Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A

A series of 2-adamantanamines with alkyl adducts of various lengths were examined for efficacy against strains of influenza A including those having an S31N mutation in M2 proton channel that confer resistance to amantadine and rimantadine. The addition of as little as one CH2 group to the methyl adduct of the amantadine/rimantadine analogue, 2-methyl-2-aminoadamantane, led to activity in vitro against two M2 S31N viruses A/Calif/07/2009 (H1N1) and A/PR/8/34 (H1N1) but not to a third A/WS/33 (H1N1). Solid state NMR of the transmembrane domain (TMD) with a site mutation corresponding to S31N shows evidence of drug binding. But electrophysiology using the full length S31N M2 protein in HEK cells showed no blockade. A wild type strain, A/Hong Kong/1/68 (H3N2) developed resistance to representative drugs within one passage with mutations in M2 TMD, but A/Calif/07/2009 S31N was slow (>8 passages) to develop resistance in vitro, and the resistant virus had no mutations in M2 TMD. The results indicate that 2-alkyl-2-aminoadamantane derivatives with sufficient adducts can persistently block p2009 influenza A in vitro through an alternative mechanism. The observations of an HA1 mutation, N160D, near the sialic acid binding site in both 6-resistant A/Calif/07/2009(H1N1) and the broadly resistant A/WS/33(H1N1) and of an HA1 mutation, I325S, in the 6-resistant virus at a cell-culture stable site suggest that the drugs tested here may block infection by direct binding near these critical sites for virus entry to the host cell.