85318-25-8Relevant academic research and scientific papers
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRα agonists
Hioki, Hideaki,Shima, Naoki,Kawaguchi, Kota,Harada, Kenich,Kubo, Miwa,Esumi, Tomoyuki,Nishimaki-Mogami, Tomoko,Sawada, Jun-ichi,Hashimoto, Toshihiro,Asakawa, Yoshinori,Fukuyama, Yoshiyasu
scheme or table, p. 738 - 741 (2009/12/03)
Riccardin C, a nuclear receptor LXRα selective agonist, is an 18-membered macrocyclic bisbibenzyl isolated from several liverworts. Synthesis of riccardin C and its seven O-methylated derivatives was accomplished. The synthetic sequence highlights an intramolecular Suzuki-Miyaura coupling in the formation of the 18-membered biaryl linkage present in riccardin C. The structure-activity relationship of these compounds suggests that all of the phenolic hydroxy groups present in riccardin C are essential for the activation of LXRα.
Total Syntheses of Riccardins A, B, and C, Cytotoxic Macrocyclic Bis(bibenzyls) from Liverworts
Gottsegen, Agnes,Nogradi, Mihaly,Vermes, Borbala,Kajtar-Peredy, Maria,Bihatsi-Karsai, Eva
, p. 315 - 320 (2007/10/02)
Di-O-methylriccardin A (3), riccardin A (1), and riccardin B (4) were synthesized by convergent schemes.Rings A and D of both riccardin A and B, as well as rings B and C of riccardin B were joined by the Ullmann ether synthesis.The aryl-aryl bond in ricca
