853182-41-9Relevant academic research and scientific papers
HMG-COA REDUCTASE INHIBITORS AND METHOD
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Page/Page column 129, (2010/02/11)
Compounds are provided having the following structure (I) and pharmaceutically acceptable salts thereof, A is (II) or (III); wherein R1, R2, R3, R4, U, V, W, Y, and n are as defined above, which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy. A method for treating the above diseases employing the above compounds is also provided.
