853192-47-9

Upstream product

• 90061-40-8 3-Brom-4-hydroxy-1-methyl-1,2-dihydrochinolin-2-on 
• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 853192-53-7 3-bromo-4-trifloxy-quinolin-2(1H)-one 
• 150255-96-2 (3‐cyanophenyl)boronic acid 

Relevant academic research and scientific papers

Synthesis of 3,4-disubstituted quinolin-2(1H)-ones via palladium-catalyzed regioselective cross-coupling reactions of 3-bromo-4-trifloxyquinolin-2(1H)-one with arylboronic acids

Palladium-catalyzed regioselective cross-coupling reactions of 3-bromo-4-trifloxyquinolin-2(1H)-one with arylboronic acids provide an efficient and practical route for the synthesis of 3,4-disubstituted quinolin-2(1H)-ones. Copyright

Synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-ones via Pd-catalyzed regioselective cross-coupling reaction and cyclization

An efficient and novel route for the synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-one 1 via palladium-catalyzed site-selective cross-coupling reaction and cyclization process was described. Reaction of 3-bromo-4-trifloxy-quinolin-2(1H)-one 3 with arylboronic acid catalyzed by PdCl2(PPh3)2 afforded 3-bromo-4-aryl-quinolin-2(1H)-one 4, which then reacted with 2-ethynylaniline 5 via Pd-catalyzed Sonogashira coupling and CuI-mediated cyclization leading to the desired 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-one 1 in good yields.