853220-52-7 Usage
Uses
CID 11210285 hydrochloride has been used as a Wnt agonist.
Biological Activity
wnt agonist 1 is a small-molecule agonist of wnt signaling pathway [1].the wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation [1].wnt agonist 1 is a cell-permeable wnt signaling pathway agonist. wnt agonist 1 induced b-catenin- and tcf-dependent transcriptional activity in a dose-dependent way with ec50 of 0.7 μm. in xenopus embryos, treatment with wnt agonist 1 (10 μm) from developmental stage 10.5 to stage 40 resulted in substantial head defects, such as diminished heads and complete loss of eyes, and reduced eyes and heads. this phenotype is similar to that which results from wnt over-expression in head specification during early embryonic development.
Biochem/physiol Actions
CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β. CID 11210285is a Wnt agonist.
references
liu j, wu x, mitchell b, et al. a small-molecule agonist of the wnt signaling pathway. angew chem int ed engl. 2005 mar 18;44(13):1987-90.
Check Digit Verification of cas no
The CAS Registry Mumber 853220-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,3,2,2 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 853220-52:
(8*8)+(7*5)+(6*3)+(5*2)+(4*2)+(3*0)+(2*5)+(1*2)=147
147 % 10 = 7
So 853220-52-7 is a valid CAS Registry Number.
853220-52-7Relevant academic research and scientific papers
Liu, Jun,Wu, Xu,Mitchell, Brian,Kintner, Chris,Ding, Sheng,Schultz, Peter G.
, p. 1987 - 1990 (2005)
(Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos trea
COMPOUNDS AND COMPOSITIONS AS WNT SIGNALING PATHWAY MODULATORS
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Page/Page column 13-14, (2008/06/13)
The invention provides a novel class of compounds and methods of using such compounds to study the activity of the Wnt signaling pathway.
