853269-06-4Relevant academic research and scientific papers
Designing the "Search pathway" in the development of a new class of highly efficient stereoselective hydrosilylation catalysts
Cesar, Vincent,Beliemin-Laponnaz, Stephane,Wadepohl, Hubert,Gade, Lutz H.
, p. 2862 - 2873 (2007/10/03)
A highly efficient class of N-heterocyclic carbene-based catalysts for the asymmetric hydrosilylation of prochiral ketones was discussed. The potential pitfalls associated with the nonlinearity in the behavior of an enantioselective catalyst in response to the variations of key reaction parameters were also described. The modular design of a new catalyst is based essentially on a single assembly step of its structural and functional subunits. It was observed that the direct coupling of oxazolines and N-heterocyclic carbenes leads to chelating C,N ancillary ligands for asymmetric catalysis that combines both an 'anchor' unit and a stereodirecting element.
