85330-74-1Relevant academic research and scientific papers
Synthesis of Di-, Tri-, and tetrasulfides through multifold carbon-sulfur cross-coupling reactions with indium tri(organothiolates) in a one-pot procedure
Lee, Phil Ho,Park, Youngchul,Park, Sangkyun,Lee, Euijae,Kim, Sunggak
scheme or table, p. 760 - 765 (2011/04/15)
Pd-catalyzed multifold (2-, 3-, and 4-fold) carbon-sulfur cross-coupling reaction of indium tri(organothiolates) with polybromonated aromatic and heteroaromatic compounds was developed in a one-pot procedure. Both 2,5-dibromopyridine and 2,6-dibromopyridi
Aminoarenethiolato-copper(I) as (pre-)catalyst for the synthesis of diaryl ethers from aryl bromides and sequential C-O/C-S and C-N/C-S cross coupling reactions
Sperotto, Elena,Van Klink, Gerard P.M.,De Vries, Johannes G.,Van Koten, Gerard
body text, p. 9009 - 9020 (2011/01/04)
A small library of 2-aminoarenethiolato-copper(I) (CuSAr) complexes was tested as (pre-)catalysts in the arylation reaction of phenols with aryl bromides. These copper(I) (pre-)catalysts are thermally stable, soluble in common organic solvents, and allow reactions of 6 h at 160 °C with low catalyst loadings of 2.5 mol %. Among the (pre-)catalysts screened, 2-[(dimethylamino)methyl]benzenethiolato-copper(I) (1c) led to the best results and provided good to excellent yields of various substituted diaryl ethers. Mechanistic studies showed that at early stages of the C-O coupling reaction the CuSAr complex is converted into CuBr(PhSAr) via selective coupling of the monoanionic arenethiolato ligand with phenyl bromide with formation of CuBr. In addition, the first results are shown involving a multi-component reaction (MCR) protocol for the in situ synthesis of propargylamines and their subsequent conversion involving a C-O cross coupling reaction. Furthermore, two examples of sequential C-O/C-S and C-N/C-S cross coupling reactions have been carried out on the same dihalo-pyridine substrate in a one-pot process with the same (CuSAr) (pre-)catalyst (overall yields 40-80%).
bis-Alkylsulfonylpyridines
Woods, S. G.,Matyas, B. T.,Vinogradoff, A. P.,Tong, Y. C.
, p. 97 - 101 (2007/10/02)
Dihalogenated pyridines, some activated with carboxylic, ester or cyano group, were allowed to react with sodium alkylmercaptides.After hydrolysis of the ester or cyano group followed by decarboxylation, bis-alkylthiopyridines with substituents at 2,3-, 2,4-, 2,5-, 2,6- and 3,5-positions were prepared.These compounds were oxidized to bis-alkylsulfonylpyridines.
Sulfur-substituted phenoxypyridines having antiviral activity
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, (2008/06/13)
Sulfur-substituted phenoxypyridines having antiviral activity are disclosed. Methods of using the sulfur-substituted phenoxypyridines to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions thereof.
