85330-81-0Relevant academic research and scientific papers
3 - Ethylsulfonyl - 2 - pyridine sulfonamide and intermediate preparation method
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Paragraph 0082-0083; 0085-0086, (2018/04/20)
The invention discloses a preparation method of 3-ethylsulfonyl-2-pyridinesulfonamide and an intermediate thereof and provides a preparation method of 3-ethylsulfonyl-2-pyridinethiol. The preparation method of 3-ethylsulfonyl-2-pyridinethiol comprises the following step of carrying out nucleophilic substitution on 2,3-diethylsulfonylpyridine and a thiolation reagent in a solvent to obtain 3-ethylsulfonyl-2-pyridinethiol, wherein the thiolation reagent is a mixture of sodium sulfide and sulfur or sodium hydrosulfide. According to the preparation method disclosed by the invention, cheap 2,3-dichloropyridine is used as a raw material, the reaction step is simple, the total yield is high, and the production cost is greatly reduced; and the preparation method is suitable for industrial production.
bis-Alkylsulfonylpyridines
Woods, S. G.,Matyas, B. T.,Vinogradoff, A. P.,Tong, Y. C.
, p. 97 - 101 (2007/10/02)
Dihalogenated pyridines, some activated with carboxylic, ester or cyano group, were allowed to react with sodium alkylmercaptides.After hydrolysis of the ester or cyano group followed by decarboxylation, bis-alkylthiopyridines with substituents at 2,3-, 2,4-, 2,5-, 2,6- and 3,5-positions were prepared.These compounds were oxidized to bis-alkylsulfonylpyridines.
