853304-11-7

Upstream product

• 853303-79-4 tert-butyl 1-hydroxy-2-methyl-3-phenylpropan-2-ylcarbamate 
• 1264296-88-9 C₁₇H₂₅NO₄ 
• 1059698-59-7 2-Benzyl-3,4-dihydroxy-2-methyl-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 86778-91-8 (+/-)-N-(tert-butoxycarbonyl)-α-methylphenylalanine 
• 853304-12-8 tert-butyl [1-benzyl-2-(benzylamino)-1-methylethyl]carbamate 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to benzylether and benzylamino derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Furan-, pyrrole-, and thiophene-based siloxydienes for syntheses of densely functionalized homochiral compounds

This review describes the methods of preparation and use of 2-(trimethylsiloxy)furan, N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsiloxy)pyrrole, and certain substituted analogues and congeners, including novel 2-(tert-butyldimethylsiloxy)thiophene, to synthesize complex carbohydrates, azasugars, polyhydroxylated alkaloids, C-glycosylated α-amino acids, amino acids bearing quaternary chiral carbon atoms, and thiosugars. Especially emphasized is the preparation of enantiomerically pure compounds of biological interest. Some mechanistic insights are presented.