85336-66-9Relevant academic research and scientific papers
Photocatalytic Isomerization of Styrenyl Halides: Stereodivergent Synthesis of Functionalized Alkenes
Zhang, Hao,Xu, Qing,Yu, Lei,Yu, Shouyun
supporting information, p. 1472 - 1477 (2019/11/03)
An efficient and general method for the isomerization of styrenyl halides under different photocatalytic conditions (fac-Ir(ppy)3 in methanol for E to Z isomerization and fluorescein in 1,4-dioxane for Z to E isomerization, respectively) is disclosed. A series of stereospecific transformations constitute preliminary validation of this strategy in the synthesis of functionalized alkenes, including two diaryl alkenes, a styrenyl boronic ester and an enyne. The photocatalytic isomerization and subsequent cross coupling reaction can be run in a one-pot manner. The stereodivergent synthesis of all four isomers of a conjugated diene, as well as the antitumor agent DMU-212 and its (Z)-isomer highlights the synthetic applicability of this method.
Stereochemistry in carbenoid formation by bromine/lithium and bromine/zinc exchange reactions of gem-dibromo compounds
Harada, Toshiro,Katsuhira, Takeshi,Hattori, Kazuhiro,Oku, Akira
, p. 7987 - 8002 (2007/10/02)
Stereochemistry in generation of lithium and zincate carbenoids by bromine/metal exchange reactions of gem-dibromo compounds with BuLi and lithium triorganozincates, respectively, has been investigated. Both lithium and zincate carbenoids derived from 1,1
Stereochemistry in Carbenoid Formation by Bromine/Lithium and Bromine/Zinc Exchange Reactions of 1,1-Dibromoalkenes: Higher Reactivity of the Sterically More Hindered Bromine Atom
Harada, Toshiro,Katsuhira, Takeshi,Oku, Akira
, p. 5805 - 5807 (2007/10/02)
Both lithium and zincate carbenoids (R1(R2)C=C(Br)M; M = Li and Zn(Bu)2Li) generated by the halogen/metal exchange reaction of 1,1-dibromoalkene 1 with BuLi and (Bu)3ZnLi, respectively, are configurationally stable at low temperature
