853563-34-5Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: Modification of the side chain
Paterson, Ian,Menche, Dirk,Hakansson, Anders E.,Longstaff, Adrian,Wong, David,Barasoain, Isabel,Buey, Ruben M.,Diaz, J. Fernando
, p. 2243 - 2247 (2007/10/03)
Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
