853688-17-2Relevant academic research and scientific papers
Palladium-catalyzed Suzuki-Miyaura coupling reactions involving β,β-dihaloenamides: Application to the synthesis of disubstituted ynamides
Couty, Sylvain,Barbazanges, Marion,Meyer, Christophe,Cossy, Janine
, p. 905 - 910 (2007/10/03)
β,β-Dihaloenamides can be successfully involved in palladium-catalyzed Suzuki-Miyaura coupling reactions. Whereas the resulting tri substituted (Z)-β-bromoenamides could participate in a second cross-coupling leading to β,β-disubstituted enamides, the (Z)-β-chloroenamides have been converted to disubstituted ynamides by an E2 elimination.
