853688-34-3

Downstream Products

• 1027335-72-3 ethyl 3-amino-7-chloro-9-(3-methoxyphenyl)thieno[3,2-b]benzothiazine-4,4-dioxide-2-carboxylate 
• 1147373-62-3 2,4-diamino-7-chloro-10-(3-methoxyphenyl)-10H-pyrimido[5,4-b][1,4]benzothiazine 5,5-dioxide 
• 1147373-16-7 3-amino-6-chloro-9-(3-methoxyphenyl)-1,9-dihydropyrazolo[4,3-b][1,4]benzothiazine 4,4-dioxide 

Relevant academic research and scientific papers

Synthesis, antimalarial activity, structure-activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs

An improved procedure for the synthesis of 3-amino-9-arylsubstituted-thieno[3,2-b]benzothiazine S,S-dioxide 2-decarboxylated is reported. Thieno-[3,2-b]benzothiazine S,S-dioxide derivatives were investigated for their abilities to inhibit β-hematin formation, hemoglobin hydrolysis and in vivo for their efficacy in rodent Plasmodium berghei. Compounds 5j-o were the most promising as inhibitors of hemoglobin hydrolysis, however, the compounds are not as efficient as chloroquine. A structure-activity relationship (SAR) study was carried out in this series. Our results allow us to determine the minimal structural requirements to produce the biological response.

Microwave-assisted synthesis of quinolones and 4H-1,4-benzothiazine 1,1-dioxides

A rapid method for the preparation of N-aryl-2-methylthio-4-oxo-1,4- dihydroquinoline-3-carbonitriles (2a-e) and N-aryl-3-methylthio-4H-1,4- benzothiazine-2-carbonitrile 1,1-dioxides (2f-o) is reported. The cyclization is accelerated by microwave irradiat