85372-56-1Relevant academic research and scientific papers
A hydrogen borrowing annulation strategy for the stereocontrolled synthesis of saturated aza-heterocycles
Armstrong, Roly J.,Chamberlain, Anna E. R.,Donohoe, Timothy J.,Paterson, Kieran J.,Twin, Heather C.
supporting information, p. 3563 - 3566 (2020/04/03)
An iridium catalyzed method for the synthesis of saturated aza-heterocycles from amines and diols is reported. A wide range of substituted heterocycles can be obtained using this approach including products bearing substituents at the C2, C3 and C4 positions. Employing water as the solvent, enantiopure diols could undergo annulation with minimal racemization, enabling the synthesis of valuable enantioenriched C3 and C4-substituted saturated aza-heterocycles.
Opposite CD Curves in Chromophoric Derivatives of 3-Substituted 5-and 6-Membered Cyclic Amines
Bettoni, Giancarlo,Cellucci, Carla
, p. 1541 - 1543 (2007/10/02)
Absolute configuration was assigned to 3-isopropylpyrrolidine by chemical correlation with R-3-isopropylsuccinic acid.The comparison between CD curves of 3-substituted piperidines, morpholines and pyrrolidine having the same chirality shows that the chiroptical properties of these five and sixmembered cyclic amine derivatives are opposite.
