853729-85-8Relevant academic research and scientific papers
A convergent, versatile route to two synthetic conjugate anti-toxin malaria vaccines
Seeberger, Peter H.,Soucy, Regina L.,Kwon, Yong-Uk,Snyder, Daniel A.,Kanemitsu, Takuya
, p. 1706 - 1707 (2004)
The synthesis of two glycosylphosphatidyl inositol (GPI) glycans that constitute the malaria toxin and promising anti-toxin vaccine constructs using a scalable route is described.
Toward the Development of the Next Generation of a Rapid Diagnostic Test: Synthesis of Glycophosphatidylinositol (GPI) Analogues of Plasmodium falciparum and Immunological Characterization
Gurale, Bharat P.,He, Yun,Cui, Xikai,Dinh, Hieu,Dhawane, Abasaheb N.,Lucchi, Naomi W.,Udhayakumar, Venkatachalam,Iyer, Suri S.
, p. 2886 - 2899 (2016/12/27)
A large number of proteins in malaria parasites are anchored using glycophosphatidylinositols (GPIs) with lipid tails. These GPIs are structurally distinct from human GPIs. Plasmodium falciparum GPIs have been considered as potential vaccine candidates be
Synthesis of the essential core of the human glycosylphosphatidylinositol (GPI) anchor
Richichi, Barbara,Luzzatto, Lucio,Notaro, Rosario,Marca, Giancarlo La,Nativi, Cristina
scheme or table, p. 88 - 93 (2011/05/12)
The biological role of GPI anchors is of paramount importance; however, we are still far from fully understanding the structure-function relationship of these molecules. One major limiting factor has been the tiny quantities available from natural sources
Assembly of a series of malarial glycosylphosphatidylinositol anchor oligosaccharides
Kwon, Yong-Uk,Soucy, Regina L.,Snyder, Daniel A.,Seeberger, Peter H.
, p. 2493 - 2504 (2007/10/03)
We report an efficient and convergent synthesis of a series of oligosaccharides comprised of the malaria GPI glycan (2 a), a promising anti-malaria vaccine candidate currently in preclinical trials and several related oligosaccharide sequences (3-8) that
