853732-36-2

Upstream product

• 591-51-5 phenyllithium 
• 452096-23-0 (2R,3R)-1-benzyl-3-phenyl-azetidine-2-carbonitrile 

Downstream Products

• 515823-92-4 (1'S,2R,3R)-(1-benzyl-3-phenylazetidin-2-yl)phenylmethanol 
• 515824-04-1 (2R,3R)-(1-benzyl-3-phenylazetidin-2-yl)phenylmethanone 

Relevant academic research and scientific papers

Azetidines as ligands in the Pd(II) complexes series

The preparation of palladium (II) complexes having sterically congested azetidines as ligands is described. Diastereomerically pure α-alkylamino and α-alkylimino azetidines react with Na2PdCl4 to afford the corresponding bidendate Pd(II) complexes, whereas 2-cyano azetidines can be used to access bidendate Pd(II) complexes containing an amino-imidate moiety. Preliminary study of the catalytic activity of these new complexes in the Suzuki cross-coupling reaction is presented.

Synthesis of enantiopure 2-acyl azetidines and the application of amino alcohols derived therefrom in enantioselective catalysis

Enantiopure 2-acyl azetidines were prepared in good yields from 2-cyano azetidines. The ketones produced were then stereoselectively reduced with sodium borohydride (with or without zinc bromide) or transformed into tertiary azetidinic amino alcohols by addition of phenyllithium. The latter compounds were found to be highly efficient catalysts for the enantioselective addition of diethylzinc to aldehydes, giving enantioselectivities up to 98%.