853737-95-8Relevant articles and documents
Direct catalytic synthesis of enantiopure 5-substituted oxazolidinones from racemic terminal epoxides
Bartoli, Giuseppe,Bosco, Marcella,Carlone, Armando,Locatelli, Manuela,Melchiorre, Paolo,Sambri, Letizia
, p. 1983 - 1985 (2007/10/03)
(Chemical Equation Presented) A venerable scaffold for asymmetric synthesis and drug development, chiral 5-substituted oxazolidinones are obtained in almost enantiomerically pure form (up to 99.9% ee) starting from racemic terminal epoxides. The salient features of this process include the very simple and convenient experimental protocol and the employment of a readily accessible catalyst and inexpensive, easily handled starting materials. An enantioconvergent approach for the total conversion of racemic epoxide into a single stereoisomeric oxazolidinone is also described.