85374-19-2Relevant academic research and scientific papers
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth
Desai, Janish,Wang, Yang,Wang, Ke,Malwal, Satish R.,Oldfield, Eric
, p. 2205 - 2215 (2016/10/22)
We synthesized potential inhibitors of farnesyl diphosphate synthase (FPPS), undecaprenyl diphosphate synthase (UPPS), or undecaprenyl diphosphate phosphatase (UPPP), and tested them in bacterial cell growth and enzyme inhibition assays. The most active compounds were found to be bisphosphonates with electron-withdrawing aryl-alkyl side chains which inhibited the growth of Gram-negative bacteria (Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa) at ～1–4 μg mL?1levels. They were found to be potent inhibitors of FPPS; cell growth was partially “rescued” by the addition of farnesol or overexpression of FPPS, and there was synergistic activity with known isoprenoid biosynthesis pathway inhibitors. Lipophilic hydroxyalkyl phosphonic acids inhibited UPPS and UPPP at micromolar levels; they were active (～2–6 μg mL?1) against Gram-positive but not Gram-negative organisms, and again exhibited synergistic activity with cell wall biosynthesis inhibitors, but only indifferent effects with other inhibitors. The results are of interest because they describe novel inhibitors of FPPS, UPPS, and UPPP with cell growth inhibitory activities as low as ～1–2 μg mL?1.
SYNTHESIS OF PHOSPHORUS-CONTAINING 3-(2,2-DICHLOROVINYL)-2,2-DIMETHYLCYCLOPROPANECARBOXYLATES
Kormachev, V. V.,Kolyamshin, O. A.,Mitrasov, Yu. N.,Anisimova, E. A.
, p. 478 - 482 (2007/10/02)
The reaction of dialkylphosphites with 2,2-dichlorocyclopropanecarbaldehyde in the presence of sodium alkoxides occurs with retention of the cyclopropane ring and leads to preparation of dialkyl-1-(2,2-dichlorocyclopropyl)-1-hydroxymethylphosphonates.By reaction of the acid chloride of 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid with dialkyl-1-alkyl(aryl)-1-hydroxymethylphosphonates, we have obtained the corresponding phosphorus-containing esters.
