853750-49-9

Upstream product

• 104266-88-8 (4S)-4-benzyl-3-pent-4-enoyl-1,3-oxazolidin-2-one 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 853750-45-5 (4S)-4-benzyl-3-{(2S)-2-[(S)-(3,4-dimethoxyphenyl)(hydroxy)methyl]-4-pentenoyl}-2-oxazolidinone 
• 853750-47-7 (4S)-4-benzyl-3-{(2S)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-4-pentenoyl}-2-oxazolidinone 

Downstream Products

• 566949-61-9 (3R)-3-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide 
• 853750-52-4 (2R,3R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-3-[(S)-(hydroxy)(3,4-methylenedioxyphenyl)methyl]tetramethylene dipivaloate 
• 853750-54-6 (2R,3R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-3-(3,4-methylenedioxybenzoyl)tetramethylene dipivaloate 

Relevant academic research and scientific papers

First enantioselective synthesis of (-)- And (+)-virgatusin, tetra-substituted tetrahydrofuran lignan

The first highly enantioselective syntheses of tetra-substituted tetrahydrofuran lignan, (-)- and (+)-virgatusin, were achieved. Hemiacetal 15 was stereoselectively obtained from Evans's syn-aldol product 8 as a single isomer. This hemiacetal 15 was converted to (-)-virgatusin via hydrogenolysis. (+)-Virgatusin was also synthesized through the same process. The enantiomeric excess of the both enantiomers was determined as more than 99% ee. The Royal Society of Chemistry 2005.