853783-18-3

Upstream product

• 68076-40-4 N¹-tert-butoxycarbonyl-N⁴-(2-cyanoethyl)-1,4-butanediamine 
• 501-53-1 benzyl chloroformate 
• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 

Downstream Products

• 1375180-08-7 C₄₃H₅₃N₃O₇ 
• 1375180-09-8 benzyl 3-(3-(3,4-bis(benzyloxy)phenyl)propanamido)propyl(4-aminobutyl)carbamate 
• 1375180-11-2 C₄₁H₄₈N₄O₅ 
• 1375180-12-3 C₆₄H₆₈N₄O₈ 
• 1375180-15-6 benzyl 4-(3-(3,4-bis(benzyloxy)phenyl)-N-(3-aminopropyl)propanamido)butyl(3-(3-(3,4-bis(benzyloxy)phenyl)propanamido)propyl)carbamate 
• 1375179-78-4 kukoamine B malate 
• 1375179-80-8 kukoamine B succinate 
• 1375179-82-0 kukoamine B lactate 
• 1375179-88-6 kukoamine B glutamate 
• 1375179-93-3 kukoamine B sulfate 
• 1375179-96-6 kukoamine B maleate 
• 1375179-97-7 kukoamine B aspartate 
• 1375180-00-9 kukoamine B phosphate 
• 97628-87-0 benzyl (4-aminobutyl)(3-(((benzyloxy)carbonyl)amino)propyl)carbamate 

Relevant academic research and scientific papers

The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate

The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.

FUNCTIONALIZED LINEAR LIGANDS AND COMPLEXES THEREOF

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF

Provided are salts of kukoamine B, their preparation method and their use in preventing and treating sepsis diseases.

SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF

Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.

Facile synthetic route to selectively protected spermidine homologues

Several selectively protected spermidine homologues were synthesized via cyanoethylation reaction of monoprotected diamines, subsequent protection of their secondary amino group, hydrolysis of nitrile to primary amide function, and final Hofmann degradati

Efficient synthesis of orthogonally protected spermidine and norspermidine derivatives

Several orthogonally protected spermidine and norspermidine derivatives have been synthesized via cyanoethylation of monoprotected 1,4-butanediamine (putrescine) or 1,3-propanediamine followed by protection of their secondary amino groups and final reduct