85387-53-7

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 62760-79-6 2-ethoxyethyl 3-ethoxycarbonyl-2-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate 
• 142619-07-6 β-ethoxyethyl 2-(m-nitrobenzylidene)acetoacetate 

Relevant academic research and scientific papers

3-amino-3-carbamoyloxyalkylacrylic acid intermediates to dihydropyridines

A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: STR1 which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: STR2 with a benzylidene compound represented by the general formula: STR3 (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: STR4 and a β-keto-ester compound represented by the general formula: (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: STR5 with the benzylidene compound of the general formula III and ammonia or its salt; or (d) reacting the 3-carbamoyloyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the β-keto-ester compound of the general formula V and ammonia or its salt.

2-Substituted or unsubstituted aminocarbonyloxyalkyl-1,4-dihydropyridines

Novel compounds having vasodilation and hypotensive effects are represented by the formula STR1 where R1 is halogen, nitro, cyano or lower alkoxy; each of R2 and R3 is lower alkyl, lower haloalkyl, lower alkoxyalkyl, aralk