853921-26-3

Basic information

• Product Name: 4-(5-Phenylthiophen-2-yl)butanoic acid
• Synonyms: 4-(5-Phenylthiophen-2-yl)butanoic acid
• CAS NO: 853921-26-3
• Molecular Formula: C₁₄H₁₄O₂S
• Molecular Weight: 246.32476
• Mol File: 853921-26-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(5-Phenylthiophen-2-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Phenylthiophen-2-yl)butanoic acid(853921-26-3)
• EPA Substance Registry System: 4-(5-Phenylthiophen-2-yl)butanoic acid(853921-26-3)

Safety Data

• Hazardous Substances Data: 853921-26-3(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 825-55-8 2-phenylthiophene 
• 854007-00-4 4-oxo-4-(5-phenyl-2-thienyl)butanoic acid 
• 20828-66-4 methyl 4-(thiophen-2-yl)butanoate 
• 591-50-4 iodobenzene 
• 16939-57-4 (E)-buta-1,3-dienylbenzene 

Downstream Products

• 858822-00-1 2-phenyl-6,7-dihydro-5H-benzo[b]thiophen-4-one 
• 1207-95-0 2-phenylbenzo[b]thiophene 
• 40808-52-4 2-phenyl-4,5,6,7-tetrahydrothiophene 

Relevant articles and documents

Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents

Parasitic platyhelminths are responsible for serious infectious diseases, such as schistosomiasis, which affect humans as well as animals across vast regions of the world. The drug arsenal available for the treatment of these diseases is limited; for example, praziquantel is the only drug currently used to treat ≥240 million people each year infected with Schistosoma spp., and there is justified concern about the emergence of drug resistance. In this study, we screened biarylalkyl carboxylic acid derivatives for their antischistosomal activity against S. mansoni. These compounds showed significant influence on egg production, pairing stability, and vitality. Tegumental lesions or gut dilatation was also observed. Substitution of the terminal phenyl residue in the biaryl scaffold with a 3-hydroxy moiety and derivatization of the terminal carboxylic acid scaffold with carboxamides yielded compounds that displayed significant antischistosomal activity at concentrations as low as 10 μm with satisfying cytotoxicity values. The present study provides detailed insight into the structure–activity relationships of biarylalkyl carboxylic acid derivatives and thereby paves the way for a new drug-hit moiety for fighting schistosomiasis.