853925-87-8Relevant articles and documents
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
Dymock, Brian W.,Barril, Xavier,Brough, Paul A.,Cansfield, Julie E.,Massey, Andrew,McDonald, Edward,Hubbard, Roderick E.,Surgenor, Allan,Roughley, Stephen D.,Webb, Paul,Workman, Paul,Wright, Lisa,Drysdale, Martin J.
, p. 4212 - 4215 (2007/10/03)
The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional a