853935-01-0Relevant academic research and scientific papers
Synthesis, characterisation and anthelmintic activity of 3-(4-acetyl-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives
Naga Sudha,Sridhar,Girija Sastry,Reddy,Sreevidya, Owk,Lavanya,Asha Jyothi,Nagesh,Sen, Saikat,Chakraborty, Raja
, p. 422 - 427 (2013/05/08)
Convectional synthesis of several coumarin-oxadiazole derivatives from starting compounds 2-hydroxy benzaldehyde and diethylmalonate has been accomplished. Successful synthesis of the derivatives has been confirmed by spectral studies i.e. UV, IR, MS and 1H NMR. All successfully synthesized compounds have been screened for in vitro anthelmintic activity by taking adult Indian earthworms Pheretima posthuma. Among all the derivatives 4-chloro derivatives have shown maximum activity when compared with the standard.
Synthesis of novel 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro- 1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones as potential anticonvulsant agents
Bhat, Mashooq A.,Siddiqui, Nadeem,Khan, Suroor A.
experimental part, p. 235 - 239 (2009/04/04)
A series of 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro-1,3,4- oxadiazol-2-yl)-2H-chromene-2-ones (6a-j) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. A majority of the compounds was active in MES tests. Compound (6e) was found to be potent and had activity at lower dose of 30 mg/kg in MES-test. All the compounds were less toxic as compared with the standard drug phenytoin.
