853935-08-7Relevant academic research and scientific papers
Synthesis of 3-(5-phenyl-1, 3,4-oxadiazol-2-yl)-2H-chromen-2-ones as anticonvulsant agents
Naga Sudha,Girija Sastry,Sai Harika,Yellasubbaiah
, p. 737 - 745 (2019/05/22)
3-(5-Phenyl-l,3,4-oxadiazol-2-yl)-2H-chromen-2-one (IVa-IVl) have been synthesized from N-benzylidene2-oxo-2#- chromene-3-carbohydrazide (IIIa-IIIl). The structure of synthesized coumarinyl oxadiazoles have been established by spectral data, elemental ana
Antitubercular activity of new coumarins
Cardoso, Silvia H.,Barreto, Milena B.,Lourenco, Maria C. S.,Henriques, Maria das Gracas M. De O.,Candea, Andre L. P.,Kaiser, Carlos R.,De Souza, Marcus V.N.
scheme or table, p. 489 - 493 (2012/01/13)
The present article describes a series of 21 N'-benzylidene-2-oxo-2H-chromene-3-carbohydrazides 4a-4v, which were synthesized and evaluated for their cell viabilities in non-infected and Mycobacterium bovis Bacillus Calmette-Guerin-infected macrophages. Subsequently, the non-cytotoxic compounds 4c, 4g, 4h, 4j, 4l and 4t were assessed against Mycobacterium tuberculosis ATCC 27294 using the microplate Alamar Blue assay and the activity expressed as the minimum inhibitory concentration in μg/mL. These compounds exhibited a significant activity (50-100μg/mL) when compared to the first-line drugs, such as pyrazinamide (PZA >100μg/mL). These results could be considered a good starting point for further studies to develop new lead compounds to treat multidrug-resistant tuberculosis. The present article describes a series of twenty-one coumarine derivatives, which were synthesized and evaluated against Mycobacterium tuberculosis.
Synthesis of novel 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro- 1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones as potential anticonvulsant agents
Bhat, Mashooq A.,Siddiqui, Nadeem,Khan, Suroor A.
experimental part, p. 235 - 239 (2009/04/04)
A series of 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro-1,3,4- oxadiazol-2-yl)-2H-chromene-2-ones (6a-j) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. A majority of the compounds was active in MES tests. Compound (6e) was found to be potent and had activity at lower dose of 30 mg/kg in MES-test. All the compounds were less toxic as compared with the standard drug phenytoin.
