85397-18-8Relevant academic research and scientific papers
(AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES
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Page/Page column 209, (2018/07/29)
Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.
Nucleophilic substitution process
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, (2008/06/13)
In a process for preparing a 2-(fluoronitrobenzene)acetonitrile by reacting a fluoronitrobenzene with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base, the temperature is maintained not higher than about 15° C. t
Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes with α-Substituted Nitriles and Esters. Direct α-Cyanoalkylation and α-Carbalkoxyalkylation of Nitroarenes
Makosza, Mieczyslaw,Winiarski, Jerzy
, p. 1494 - 1499 (2007/10/02)
Carbanions generated from alkanenitriles bearing α-chloro, α-OR, or α-SR groups and from aliphatic esters bearing α-SR groups react with mononitroarenes to replace hydrogen atoms of the nitroaromatic ring ortho or para to the nitro group with α-cyanoalkyl or α-carbalkoxyalkyl substituents.The nucleophilic replacement of hydrogen with such carbanions proceeds faster than substitution of halogen ortho or para to the nitro group.
Nucleophilic substitution process
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, (2008/06/13)
2-(Fluoronitrobenzene)alkyl cyanides are prepared by reacting a fluoronitrobenzene with an alpha-substituted alkyl cyanide in a substantially anhydrous aprotic solvent and in the presence of a base so that the alkyl cyanide reactant undergoes a nucleophil
