854008-26-7

Basic information

• Product Name: Benzo[1,2-b:5,4-b]difuran, 2,3-dihydro- (9CI)
• Synonyms: Benzo[1,2-b:5,4-b]difuran, 2,3-dihydro- (9CI)
• CAS NO: 854008-26-7
• Molecular Formula: C10H8O2
• Molecular Weight: 160.16932
• Mol File: 854008-26-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzo[1,2-b:5,4-b]difuran, 2,3-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzo[1,2-b:5,4-b]difuran, 2,3-dihydro- (9CI)(854008-26-7)
• EPA Substance Registry System: Benzo[1,2-b:5,4-b]difuran, 2,3-dihydro- (9CI)(854008-26-7)

Safety Data

• Hazardous Substances Data: 854008-26-7(Hazardous Substances Data)

Upstream product

• 57052-75-2 2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran 
• 108-46-3 recorcinol 
• 63807-84-1 1,3-bis-(2-chloro-ethoxy)-benzene 
• 854008-25-6 1,5-dibromo-2,4-bis(2-chloroethoxy)benzene 

Relevant articles and documents

A furan ring expansion approach to the synthesis of novel pyridazino-psoralen derivatives

A convenient preparation of the parent tetrahydrobenzodifuran 2 was developed from resorcinol. The oxidation of one or both furan rings of this key intermediate was accomplished with DDQ and the resulting benzodifuran was subsequently reacted with 3,6-dimethoxycarbonyl-1,2,4,5-tetrazine to afford the expected pyridazino-psoralen derivative in good yield. This simple method allowed the efficient preparation of a pyridazino-psoralen derivative with a formyl group at C-7, which was introduced by directed ortho-lithiation in the intermediate 2. An aminoalkyl side-chain was also introduced to the tetracyclic skeleton through the aldehyde functionality in a reductive amination process, which was accompanied by an unprecedented reduction of the pyridazine ring.