854044-50-1 Usage
Chemical structure
A derivative of imidazole, a five-membered heterocyclic compound containing nitrogen, with a cyano group (carbon-nitrogen triple bond) and a trimethylsilyl group (silicon-based organic group).
Functional groups
Contains a cyano group and a trimethylsilyl group, which contribute to its versatility in organic synthesis.
Application
Used in organic synthesis and pharmaceutical research as a versatile building block for the synthesis of various organic compounds.
Importance
Serves as an important intermediate in the production of pharmaceuticals and agrochemicals.
Research and development
Utilized in the research and development of new drugs and materials.
Molecular weight
Approximately 236.39 g/mol (calculated from the chemical formula).
Physical state
Likely a solid at room temperature, based on the presence of a cyano group and a trimethylsilyl group.
Solubility
Solvent compatibility is not provided, but it is likely soluble in common organic solvents such as dichloromethane, dimethyl sulfoxide (DMSO), or acetonitrile, due to its imidazole core and other functional groups.
Stability
The stability of the compound is not explicitly mentioned, but it is generally stable under normal laboratory conditions, as it is used in research and synthesis. However, it may be sensitive to moisture or air due to the presence of the trimethylsilyl group.
Check Digit Verification of cas no
The CAS Registry Mumber 854044-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,4,0,4 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 854044-50:
(8*8)+(7*5)+(6*4)+(5*0)+(4*4)+(3*4)+(2*5)+(1*0)=161
161 % 10 = 1
So 854044-50-1 is a valid CAS Registry Number.
854044-50-1Relevant articles and documents
HETEROARYL ALKYLENE SUBSTITUTED 2-OXOQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A
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Paragraph 0268, (2021/12/31)
Disclosed herein are certain heteroaryl alkylene substituted 2-oxoquinazoline derivatives of Formula (I): (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
IMIDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE OR INFLAMMATORY DISEASES OR CANCERS
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Page/Page column 53, (2018/03/25)
Compounds of formula (I) and salts thereof: wherein R1, R2, R3, a, X1, X2, X3, X4, and X5 are as defined hereinbefore. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
METHOD OF INHIBITING C-KIT KINASE
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Page/Page column 75, (2008/06/13)
A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.
