854159-20-9Relevant articles and documents
First selective lithiation of pyridylpiperazines: Straightforward access to potent pharmacophores
Lou?rat, Frédéric,Gros, Philippe,Fort, Yves
, p. 4761 - 4768 (2007/10/03)
The three isomers of pyridylpiperazines have been lithiated for the first time. The use of a superbase, an aminoalkoxide containing lithiating agent overcomes the chelating influence of the basic piperazine nitrogens, so that selective mono lithiation occurred alpha to pyridine nitrogen. This methodology offers a new access to diverse potent pharmacophores not easily prepared by other routes.