85417-41-0 Usage
Uses
Used in Pharmaceutical Industry:
TRIS(2,6-DIMETHOXYPHENYL)PHOSPHINE is used as a catalyst in the preparation of chiral building blocks via hydroalkynylation reactions or ynolates. These chiral building blocks are essential for the synthesis of various pharmaceutical compounds, as they can be used to create enantiomerically pure drugs with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
TRIS(2,6-DIMETHOXYPHENYL)PHOSPHINE is used as a catalyst for three-component aza-Morita-Baylis-Hillman reactions (aza-MBH). This reaction is an atom-economic synthesis of nitrogen heterocycles and ynenoates from alkynes, which are important intermediates in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and natural products.
Used in Organic Chemistry:
TRIS(2,6-DIMETHOXYPHENYL)PHOSPHINE is used as a catalyst for oxycylations of allendiols. This reaction allows for the selective formation of functionalized diols, which are valuable building blocks in organic synthesis and can be used in the preparation of various biologically active compounds.
Used in Asymmetric Catalysis:
TRIS(2,6-DIMETHOXYPHENYL)PHOSPHINE is used as a ligand in enantioselective aldol reactions. These reactions are crucial for the synthesis of chiral compounds, which are often found in biologically active molecules and pharmaceuticals. The use of this ligand improves the enantioselectivity of the reaction, leading to the formation of the desired enantiomer with high selectivity.
Used in Cross-Coupling Reactions:
TRIS(2,6-DIMETHOXYPHENYL)PHOSPHINE is used as a ligand in Pd-mediated cross-coupling, Pdand Cu-mediated benzannulation reactions, and copper-mediated dimerization reactions. These reactions are essential for the formation of carbon-carbon and carbon-heteroatom bonds, which are fundamental in the synthesis of complex organic molecules, including pharmaceuticals and advanced materials. The use of this ligand enhances the efficiency and selectivity of these reactions, allowing for the preparation of target molecules with high yields and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 85417-41-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,4,1 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 85417-41:
(7*8)+(6*5)+(5*4)+(4*1)+(3*7)+(2*4)+(1*1)=140
140 % 10 = 0
So 85417-41-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H27O6P/c1-25-16-10-7-11-17(26-2)22(16)31(23-18(27-3)12-8-13-19(23)28-4)24-20(29-5)14-9-15-21(24)30-6/h7-15H,1-6H3
85417-41-0Relevant articles and documents
Some Unusual Properties of Tris(2,6-dimethoxyphenyl)phosphine Sulfide and the Related Compounds
Wada, Masanori,Kanzaki, Mitsuyuki,Fujiwara, Masanobu,Kajihara, Kazuhisa,Erabi, Tatsuo
, p. 1782 - 1786 (2007/10/02)
The title sulfide 3P=S reacted with acids to form a novel mercaptophosphonium salt X, solution thermolysis of which in the absence or presence of triphenylphosphine resulted in the unusual desulfurization to give the tertiary phosphonium salts X. (2,6)3P=S also reacted with alkyl iodides or bromides under mild conditions to give stable (alkylthio)phosphonium salts X (R=Me, Et, n-Bu), which reacted with thiols at room temperature in the presence of a catalytic amount of the tertiary phosphine (2,6)3P to give X and unsymmetrical disulfides.
Facile Synthesis of Alkylthiophosphonium Salts of Tris(2,6-dimethoxyphenyl)phosphine and Their Reactions with Thiols
Wada, Masanori,Kanzaki, Mituyuki,Fujiwara, Masanobu,Kajihara, Kazuhisa,Erabi, Tatsuo
, p. 867 - 870 (2007/10/02)
Tris(2,6-dimethoxyphenyl)phosphine sulfide reacted with alkyl iodides or bromides under mild conditions to give stable alkylthiophosphonium salts, which reacted with thiols at room temperature in the presence of a catalytic amount of tris(2,6-dimethoxyphenyl)phosphine to give the tertiary phosphonium salt and unsymmetrical disulfides.
A Highly Basic and Nucleophilic Triphenylphosphine, Tris(2,4,6-trimethoxyphenyl)phosphine, and Related Compounds
Wada, Masanori,Higashizaki, Shogo,Tsuboi, Aki
, p. 467 - 490 (2007/10/02)
A series of methoxy substituted triphenylphosphines, R3-nPhnP , and their tertiary phosphonium perchlorates have been prepared.The basicity of the title compound, (1), in acetone was f
PHOSPHORORGANISCHE VERBINDUNGEN 101. TERTIAERE PHOSPHINE MIT ORTHOALKOXYPHENYL-GRUPPEN. Synthese und Eigenschaften
Horner, L.,Simons, G.
, p. 189 - 210 (2007/10/02)
Alkylphenylethers, ortho-lithiated in good yields, are transformed according to scheme (1) to the triarylphosphines ArPPh2, Ar2PPh and Ar3P (Ar contains in all cases an ortho-alkoxy group) (Table 1.).Hydroquinonedialkylethers can be lithiated twice, forming the compounds 102 and 103.Table 2 summarizes some arylalkylethers (71 - 101) which were lithiated; table 7 presents 12 new arylalkylethers.The syntheses of triarylphosphines with one or two bulky groups (105 - 110) and of triarylphosphines with one or two 3,4-dialkoxyphenyl groups (111 - 114) are reported.The 31P-spectra of the compounds prepared are discussed with respect to the validity of the Tolman-rule.
