85432-36-6Relevant articles and documents
N and O-isopropyl isomers of barbital and phenobarbital: Physicochemical and pharmacological properties
Menez,Bourin,Colombel,et al.
, p. 521 - 529 (2007/10/02)
Univocal synthesis of O and N isopropylated derivatives of barbital and phenobarbital is proposed. Properties of those compounds in solution (pka and lipophilicity) show important differences. However the phenobarbital derivatives keep the anticonvulsant