854357-42-9Relevant academic research and scientific papers
Transition-Metal-Free Alkylation and Acylation of Benzoxazinones with 1,4-Dihydropyridines
Byun, Youjung,Moon, Junghyea,An, Won,Mishra, Neeraj Kumar,Kim, Hyung Sik,Ghosh, Prithwish,Kim, In Su
, p. 12247 - 12256 (2021)
The direct functionalization of N-heterocycles is a vital transformation for the development of pharmaceuticals, functional materials, and other chemical entities. Herein, the transition-metal-free alkylation and acylation of C(sp2)-H bonds in biologically relevant 2-benzoxazinones with 1,4-dihydropyridines as readily accessible radical surrogates is described. Excellent functional group compatibility and a broad substrate scope were attained. Gram-scale reaction and transformations of the synthesized adducts via Suzuki coupling with heteroaryl boronic acids demonstrated the synthetic potential of the developed protocol.
