854371-79-2Relevant academic research and scientific papers
Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition
Hu, Yonghan,Xing, Li,Thomason, Jennifer R.,Xiang, Jason,Ipek, Manus,Guler, Satenig,Li, Huanqiu,Sabatini, Joshua,Chockalingam, Priya,Reifenberg, Erica,Sheldon, Richard,Morris, Elisabeth A.,Georgiadis, Katy E.,Tam, Steve
, p. 6800 - 6803 (2011)
Design, synthesis and structure-activity relationship of a series of biphenylsulfonamido-3-methylbutanoic acid based aggrecanase-1 inhibitors are described. In addition to robust aggrecanase-1 inhibition, these compounds also exhibit potent MMP-13 activit
Biaryl sulfonamides and methods for using same
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Page/Page column 28, (2008/06/13)
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
