854457-16-2Relevant academic research and scientific papers
Cyanomethyl substituted N-Acyl Tryptamines
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Page/Page column 34, (2009/03/07)
The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula I in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and
Chemoenzymatic preparation of the enantiomers of β-tryptophan ethyl ester and the β-amino nitrile analogue
Li, Xiang-Guo,Kanerva, Liisa T.
, p. 1709 - 1714 (2007/10/03)
Racemic α-tryptophan was chemoselectively transformed into the enantiomers of β-tryptophan ethyl ester. The key step in achieving enantiopurity was the N-acylation of the 3-amino-4-(3-indolyl)butanenitrile intermediate with Candida antarctica lipase A (CAL-A). The enzymatic N-acylation of racemic β-tryptophan ethyl ester was also studied. CAL-A was highly (R)-enantioselective in the present kinetic resolutions, leading to a mixture of the butanamide product with an (R)-configuration and the unreacted starting material with an (S)-configuration at 50% conversion.
