85446-34-0Relevant academic research and scientific papers
SYNTHESIS OF (3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL) DERIVATIVES OF HETEROCYCLIC BASES
Holy, Antonin,Rosenberg, Ivan,Dvorakova, Hana
, p. 2470 - 2501 (2007/10/02)
Analogs of antiviral 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA, I), containing modofied heterocyclic base, were prepared from racemic or (S)-N-(2,3-dihydroxypropyl) derivatives II.Compounds II are heated with chloromethylphosphonyl dichlor
Synthesis of aliphatic nucleoside analogues with potential antiviral activity
Colla,Busson,De Clercq,Vanderhaeghe
, p. 569 - 576 (2007/10/02)
The synthesis of a series of double-modified adenosine and 8-aza-adenosine analogues, altered in the 6-position of the base and having the sugar moiety replaced by an acyclic hydroxylated side chain is described. Also, some aliphatic derivatives of 5-iodo- and E-5-(2-bromovinyl)uracil were prepared. Of all these compounds, only 6-hydroxylamino-9-(2,3-dihydroxypropyl)purine displayed some antiviral activity when tested in primary rabbit kidney cell cultures against vesicular stomatitis, vaccinia or herpes simplex virus.
