85448-11-9Relevant academic research and scientific papers
The cross-aldol reaction of hexafluoroacetone (HFA) with ketones catalyzed by an acid
Komata, Takeo,Matsunaga, Kei,Hirotsu, Yoshiki,Akiba, Shinya,Ogura, Katsuyuki
, p. 902 - 909 (2008/03/14)
The cross-aldol reactions of hexafluoroacetone (HFA) and ketones using an acid catalyst are reported. When concentrated sulfuric acid was employed as the catalyst, HFA reacted regioselectively with various ketones at 50-100 °C to give the aldol adducts (6) in good yields. The reaction is initiated by an acid-catalyzed transformation of the ketone into the corresponding enol that reacts with HFA. The obtained adducts (6) can be reduced with hydrogen under a Ru/C catalyst to lead to the corresponding fluorine-containing diols (13).
Processes for producing fluorine-containing 2,4-diols and their derivatives
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Page/Page column 8, (2008/06/13)
A process for producing a fluorine-containing 2,4-diol represented by the formula [4], wherein R1 represents a hydrogen atom or an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7; R2 represents an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7, a phenyl group, or a substituted phenyl group; and R1 and R2 are optionally bonded to each other to form a ring, includes reducing a hydroxy ketone represented by the formula [3], wherein R1 and R2 are defined as above, by hydrogen in the presence of a ruthenium catalyst.
FLUORINE-CONTAINING TERPENE ANALOGS. IV. 9,9,9,10,10,10-HEXAFLUORO-p-MENTHANE-1,8-DIOL (HEXAFLUOROTERPINE)
Zalesskaya, I. M.,Fialkov, Yu. A.,Parakhnenko, A. I.,Yagupol'skii, I. M.
, p. 1890 - 1894 (2007/10/02)
The oxidation of trans-e,e-4-(2-hydroxyperfluoroisopropyl)cyclohexanol with pyridinium chlorochromate gave the corresponding cyclohexanone.The reaction of this product with methylmagnesium iodide gave cis- and trans-9,9,9,10,10,10-hexafluoro-p-menthane-1,8-diol, which is a fluorinated analog of natural terpine.
REGIOSPECIFIC α-HEXAFLUOROISOPROPYLIDENATION OF KETONES USING HEXAFLUOROACETONE
Ishihara, Takashi,Shinjo, Hiroshi,Inoue, Yoshihisa,Ando, Teiichi
, p. 1 - 20 (2007/10/02)
Hexafluoroacetone (HFA) reacted regiospecifically with various enol silyl ethers at -30 to -35 deg C in the presence of a Lewis acid to give HFA aldols, or α-bis(trifluoromethyl)hydroxymethyl carbonyl compounds, in good yields.The reaction of HFA with die
