854497-52-2

Upstream product

• 122-78-1 phenylacetaldehyde 
• 343338-28-3 (S)-2-methylpropane-2-sulfinamide 

Downstream Products

• 118867-00-8 (R)-(1-Amino-2-phenylethyl)phosphonsaeure-diethylester 
• 1023377-93-6 (S)-2-methyl-propane-2-sulfinic acid ((R)-1-(R)-cyclohexa-2,4-dienyl-2-phenylethyl)-amide 
• 1023378-13-3 C₁₈H₂₅NOS 
• 948843-78-5 C₂₂H₂₇NO₃ 
• 948843-77-4 C₂₂H₂₇NO₃ 
• 948843-56-9 C₂₆H₃₅NO₄S 
• 948843-57-0 C₂₆H₃₅NO₄S 
• 1329450-72-7 (S,R)-5-[(S)-benzyl-(tert-butanesulfinylamino)methyl]furan-2(5H)-one 
• 1329450-75-0 (R,R)-5-[(S)-benzyl-(tert-butanesulfinylamino)methyl]furan-2(5H)-one 

Relevant academic research and scientific papers

KHSO4-mediated condensation reactions of tert-butanesulfinamide with aldehydes. Preparation of tert-butanesulfinyl aldimines

Optically pure tert-butanesulfinyl aldimines 1 were prepared by direct condensation of chiral tert-butanesulfinamide 3 with aldehydes 2 in high yields in the presence of KHSO4. The main advantage of KHSO4 is that it is applicable to the condensation reactions of a variety of aldehydes, including electron deficient and electron rich (hetereo)aromatic aldehydes, as well as aliphatic aldehydes.

Efficient synthesis of Xaa-Gly type (Z)-chloroalkene dipeptide isosteres via organocuprate mediated reduction

A highly stereoselective synthesis of (Z)-chloroalkene dipeptide isosteres (CADIs) of the Xaa-Gly type has been achieved. Treatment of an allylic gem-dichloride with an organocuprate provided (Z)-chloroalkene formation corresponding to an Xaa-Gly type CAD

Asymmetric vinylogous Mannich reactions: A versatile approach to functionalized heterocycles

Asymmetric vinylogous Mannich reaction (VMR) of 2-(tert- butyldimethylsilyloxy)furan (TBSOF, 1) with (RS)- or (S S)-t-BS-imines (3) furnished 5-aminoalkylbutenolides 7a-k in 75-87% yields with anti/syn ratios ranging from 75:25 to 97:3. Butenolides 7a-f,k were readily converted into substituted lactones 8 and 5 and 6-substituted 5-hydroxypiperidin-2-ones 11a-g, which are, in turn, key intermediates for the synthesis of many bioactive compounds.

Desymmetrization of metallated cyclohexadienes with chiral N-tert-butanesulfinyl imines

This communication describes the desymmetrization of various achiral metallated cyclohexadienes with a series of chiral N-tert-butanesulfinyl imines. Depending on the metal used, either the symmetrical diene (dicyclohexadienyl- zinc) or the desymmetrized