85452-84-2Relevant academic research and scientific papers
A new strategy for deprotonative functionalization of aromatics: Transformations with excellent chemoselectivity and unique regioselectivities using t-Bu-P4 base
Imahori, Tatsushi,Kondo, Yoshinori
, p. 8082 - 8083 (2003)
A new strategy for deprotonative functionalization of aromatics using t-Bu-P4 base has been developed, and highly chemoselective transformations have been achieved with unique regioselectivities. Copyright
Potent inhibitors of protein farnesyltransferase: Heteroarenes as cysteine replacements
Shen, Wang,Fakhoury, Stephen,Donner, Greg,Henry, Kenneth,Lee, Jang,Zhang, Haichao,Cohen, Jerry,Warner, Robert,Saeed, Badr,Cherian, Sajeev,Tahir, Stephen,Kovar, Peter,Bauch, Joy,Ng, Shi-Chung,Marsh, Kennan,Sham, Hing,Rosenberg, Saul
, p. 703 - 708 (2007/10/03)
Synthesis and biological evaluation of heteroarenes as reduced cysteine replacements are described. Of the heteroaryl groups examined with respect to FT inhibitor FTI-276 (1), pyridyl was the replacement found to be most effective. Substitutions at C4 of the pyridyl moiety did not affect the in vitro activity. Compound 9a was found to have moderate in vivo bioavailability.
REACTION DE LA BROMO-3 PYRIDINE AVEC LE DIISOPROPYLAMIDURE DE LITHIUM. MECANISMES DE METALLATION ET DE MIGRATION D'HALOGENE. REGIOSELECTIVITE DE L'ADDITION POLAIRE SUR LA PYRIDYNE-3,4
Mallet, M.,Queguiner, G.
, p. 3035 - 3042 (2007/10/02)
3-bromo pyridine behaviour towards lithium diisopropyl amide (LDA) in THF is studied.A careful study of the experimental conditions point to a metallation reaction in a position 4 and a "halogen dance" mechanism with isomerisation into a 4-bromo pyridine.Conversion into diisopropylamino compounds occurs simultaneously with a 3 oriented elimination-addition (EA) reaction from transient isomeric lithio-derivatives and a competing addition-elimination (AE) mechanism from the in situ formed 4-bromo pyridine.
