85460-73-7

Upstream product

• 85460-77-1 o-methoxycarbonyl-2,3,6-trimethylphenol-4-sulfonyl chloride 
• 101836-20-8 2,3,5-trimethyl-4-hydroxyphenyl thiocyanate 

Downstream Products

• 85460-72-6 α-thiotocopherol acetate 
• 101836-22-0 3-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-butyric acid methyl ester 
• 85460-74-8 di(2,3,6-trimethyl-4-hydroxyphenyl) disulfide 
• 107697-36-9 2-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-2-methyl-succinic acid dimethyl ester 
• 101836-23-1 3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-3-methyl-butyric acid methyl ester 
• 85460-71-5 1-thio-α-tocopherol 
• 101836-32-2 2,3,6-Trimethyl-4-((E)-3,7,11,15-tetramethyl-hexadec-1-enylsulfanyl)-phenol 
• 261929-91-3 E_.Z, RS, RS, RS-phytyl-trimethyl-hydroxy-benzenethiol 
• 101836-33-3 4,5,7,8-Tetramethyl-4-(4,8,12-trimethyl-tridecyl)-thiochroman-6-ol 
• 101836-21-9 3-(4-hydroxy-2,3,5-trimethyl-phenylsulfanyl)-propionic acid methyl ester 
• 101836-34-4 S-(3,3-dimethylallyl)-2,3,5-trimethyl-4-hydroxybenzenethiol 
• 891188-02-6 [1-(4-Hydroxy-2,3,5-trimethyl-phenylsulfanyl)-cyclobutyl]-acetic acid methyl ester 
• 107697-41-6 6-Benzyloxy-2,5,7,8-tetramethyl-2-((Z)-4,8,12-trimethyl-tridec-1-enyl)-thiochroman 
• 107697-40-5 6-Benzyloxy-2,5,7,8-tetramethyl-thiochroman-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Spiro derivatives as lipoxygenase inhibitors

The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful

Tocopherol, tocotrienol, other chromane, and their side chain deriv. and method for using the same

The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.

Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.

Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and whe

Tocopherols, tocotrienols, other chroman and side chain derivatives and uses therof

The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; R1is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R4is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.

Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, est

2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-hydroxythiochroman (DL-α-thiotocopherol)

DL-α-Thiotocopherol was obtained in the reaction of 2,3,6-trimethyl-4-mercaptophenol or di(2,3,6-trimethyl-4-hydroxyphenyl) disulfide with 3,7,11,15-tetramethyl-1-hexadecen-3-ol (isophytol).