854627-73-9

Basic information

• Product Name: 4-BROMO-3-METHYL-5-NITROBENZONITRILE
• Synonyms: 4-BROMO-3-METHYL-5-NITROBENZONITRILE
• CAS NO: 854627-73-9
• Molecular Formula: C₈H₅BrN₂O₂
• Molecular Weight: 241.04
• Mol File: 854627-73-9.mol

Chemical Properties

• Melting Point: 100-103 °C
• Boiling Point: 301.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.70±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-BROMO-3-METHYL-5-NITROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-METHYL-5-NITROBENZONITRILE(854627-73-9)
• EPA Substance Registry System: 4-BROMO-3-METHYL-5-NITROBENZONITRILE(854627-73-9)

Safety Data

• Hazardous Substances Data: 854627-73-9(Hazardous Substances Data)

Upstream product

• 6933-10-4 amino-5-bromo-2-toluene 
• 41963-20-6 4-bromo-3-methylbenzonirtile 

Downstream Products

• 412944-46-8 methyl 4-bromo-3-methyl-5-nitrobenzoate 
• 850335-09-0 methyl 4-hydroxy-3-methyl-5-nitrobenzoate 
• 408533-82-4 4-bromo-3-methyl-5-nitro-benzoic acid 
• 849353-44-2 4-hydroxy-3-methyl-5-nitro-benzonitrile 
• 1002762-19-7 C₈H₇BrN₂O 

Relevant articles and documents

PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or hydrate thereof, wherein: the group X-Y is -NHSO2- or -SO2NH-; Z is a monocyclic aryl or heteroaryl group, each of which is optionally substituted by one ormore substituents selected from alkyl, cycloalkyl, halo, alkoxy, CN, haloalkyl and OH; R1 is H or alkyl; R2 is selected from COOH and a tetrazolyl group; R3 is selected from H, C land alkyl; R4 is selected from H and halo; R5 is selected from H, alkyl, haloalkyl, SO2-alkyl,Cl, alkoxy, OH, CN, hydroxyalkyl, alkylthio, heteroaryl, cycloalkyl, heterocycloalkyl andhaloalkoxy; R6 is H; R7 is selected from H, CN, haloalkyl, halo, SO2-alkyl,SO2NR12R13, heteroaryl, CONR10R11 and alkyl, wherein said heteroaryl group is optionallysubstituted by one or more substituents selected from alkyl, halo, alkoxy, CN, haloalkyl and OH; R8 is selected from H, alkyl, haloalkyl and halo; and R9 is H, alkyl or halo; R10 and R11 are each independently H or alkyl; and R12 and R13 are each independently H or alkyl. Further aspects of the invention relate to such compounds for use in the field of immuno- oncology and related applications. Another aspect of the invention relates to compounds of formulae (la) and (lb).

Nonsteroidal glucocorticoid agonists: Tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (Transrepression/Transactivation) efficacy selectivity

The synthesis and biological activity of tetrahydronaphthalene derivatives coupled to various heterocycles are described. These compounds are potent glucocorticoid receptor agonists with efficacy selectivity in an NFκB glucocorticoid receptor (GR) agonist assay (representing transrepression effects) over an MMTV GR agonist assay (representing transactivation effects). Quinolones, indoles, and C- and N-linked quinolines are some of the heterocycles that provide efficacy selectivity. For example, the isoquinoline 49D1E2 has NFκB agonism with pIC50 of 8.66 (89%) and reduced efficacy in MMTV agonism (6%), and the quinoline 55D1E1 has NFκB agonism with pIC 50 of 9.30 (101%) and reduced efficacy in MMTV agonism with pEC 50 of 8.02 (47%). A description of how a compound from each class is modeled in the active site of the receptor is given.