85464-10-4Relevant academic research and scientific papers
Control over absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry in the synthesis of allylically substituted alkenes from diphenylphosphinoyl epoxy alcohols
Clayden, Jonathan,McElroy, Andrew B.,Warren, Stuart
, p. 1913 - 1934 (2007/10/02)
Regioselective ring-openings of epoxy alcohols bearing a diphenylphosphinoyl (Ph2PO) group give diols which can undergo stereospecific Horner-Wittig elimination.This method was used to make allylic alcohols, unsaturated β-hydroxy sulfides, homoallylic alcohols and unsaturated amino acids, with control over their absolute (R,S), relative (syn,anti) and geometrical (E,Z) stereochemistry.
