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CAS

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85469-67-6

1-(4-cyanophenyl)-4-propylpiperazine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 85469-67-6 Structure

  • Basic information

    1. Product Name: 1-(4-cyanophenyl)-4-propylpiperazine
    2. Synonyms:
    3. CAS NO:85469-67-6
    4. Molecular Formula:
    5. Molecular Weight: 229.325
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 85469-67-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(4-cyanophenyl)-4-propylpiperazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(4-cyanophenyl)-4-propylpiperazine(85469-67-6)
    11. EPA Substance Registry System: 1-(4-cyanophenyl)-4-propylpiperazine(85469-67-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 85469-67-6(Hazardous Substances Data)

85469-67-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 85469-67-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,4,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 85469-67:
(7*8)+(6*5)+(5*4)+(4*6)+(3*9)+(2*6)+(1*7)=176
176 % 10 = 6
So 85469-67-6 is a valid CAS Registry Number.

85469-67-6Relevant articles and documents

Synthesis of novel succinamide derivatives having a 5,11-dihydro-6h- pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. II

Watanabe, Toshihiro,Kakefuda, Akio,Kinoyama, Isao,Takizawa, Kenji,Hirano, Seiko,Shibata, Hiroshi,Yanagisawa, Isao

, p. 1458 - 1469 (1997)

A series of succinamide derivatives containing the 5,11-dihydro-6H- pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton (6a-z) was prepared and evaluated for binding affinity to muscarinic receptors in vitro and for antagonism of bradycardia and salivation in vivo in comparison with AF-DX 116 (1a). Structure-activity relationships (SAR) studies in vitro indicated that the 4-(4-alkyl-1-piperazinyl)benzylamino moiety plays a crucial role in enhancing the infinity for M2 muscarinic receptors. Compound 6y, containing a 4-(4-isopropyl-1-piperazinyl)benzylmethylamino moiety, exhibited the highest affinity for M2 muscarinic receptors (pK(i) = 9.2), being 200 times as potent as 1a, and compound 6u, containing a 4-(4-ethyl-1- piperazinyl)benzylethylamino moiety, showed the highest selectivity for M2 over M3 muscarinic receptors (M3/M2 ratio=320). Both 6y and 6u antagonized the oxotremorine-induced bradycardia in rats after intravenous or oral administration. Oral evaluation in conscious dogs showed that the efficacy for increasing the heart rate was at least 3-fold greater than that of 1a.

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