85470-72-0Relevant academic research and scientific papers
Metabolic Formation of 4-Methyl-4H-1,3,2-benzodioxaphosphorins from Bis(o-ethylphenyl) Phenylphosphonates in House Flies
Wu, Shao-Yong,Ito, Shigekazu,Eto, Morifusa
, p. 2935 - 2942 (2007/10/02)
Bis(4-chloro-2-ethylphenyl) phenylphosphonate was metabolically transformed into the corresponding cyclic ester, i.e., 6-chloro-4-methyl-2-phenyl-4H-1,3,2-benzodioxaphosphorin 2-oxide, in houseflies in vivo.In a p-unsubstituted analog, hydroxylation at the para-position of an ester linkage occurred preferably to alpha-hydroxylation with subsequent cyclization.The cyclization was diastereomerically selective, giving predominantly the cis ester.The biological activities of synthesized and related cyclic esters were similar to but weaker than saligenin cyclic phosphorus esters lacking a methyl group at the 4-position.
