854756-74-4

Usage

General Description

ALB-109564 is a chemical compound with the molecular formula C24H29N3O2. It is an experimental drug being developed for the treatment of various cancers, including breast and ovarian cancer. ALB-109564 is a potent antitumor agent that works by inhibiting the growth of cancer cells and inducing apoptosis. It has shown promising results in preclinical studies, demonstrating a high level of efficacy and a good safety profile. Additionally, ALB-109564 has shown potential for combination therapy with other anticancer drugs, highlighting its versatility in the treatment of cancer. Further research and clinical trials are needed to fully understand the potential of ALB-109564 in cancer therapy.

Upstream product

• 2468-21-5 catharinthine 
• 90012-96-7 10-iodocatharanthine 
• 1328885-36-4 10-methylthiocatharanthine 
• 1328885-51-3 10'-thiomethylanhydrovinblastine 
• 2182-14-1 vindoline 

Relevant academic research and scientific papers

10′-fluorovinblastine and 10′-fluorovincristine: Synthesis of a key series of modified vinca alkaloids

A study on the impact of catharanthine C10 and C12 indole substituents on the biomimetic Fe(III)-mediated coupling with vindoline led to the discovery and characterization of two new and substantially more potent derivatives, 10′-fluorovinblastine and 10′-fluorovincristine. In addition to defining a pronounced and unanticipated substituent effect on the biomimetic coupling, fluorine substitution at C10′, which minimally alters the natural products, was found to uniquely enhance the activity 8-fold against both sensitive (IC50 = 800 pM, HCT116) and vinblastine-resistant tumor cell lines (IC50 = 80 nM, HCT166/VM46). As depicted in the X-ray structure of vinblastine bound to tubulin, this site resides at one end of the upper portion of the T-shaped conformation of the tubulin-bound molecule, suggesting that the 10′-fluorine substituent makes critical contacts with the protein at a hydrophobic site uniquely sensitive to steric interactions.

10'-FLUORINATED VINCA ALKALOIDS PROVIDE ENHANCED BIOLOGICAL ACTIVITY AGAINST MDR CANCER CELLS

A 10'-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10'-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10'-unsubstituted vinca alkaloid.