854774-17-7Relevant articles and documents
Biarylether amide quinolines as liver X receptor agonists
Bernotas, Ronald C.,Singhaus, Robert R.,Kaufman, David H.,Ullrich, John,Fletcher III, Horace,Quinet, Elaine,Nambi, Ponnal,Unwalla, Rayomand,Wilhelmsson, Anna,Goos-Nilsson, Annika,Farnegardh, Mathias,Wrobel, Jay
experimental part, p. 1663 - 1670 (2009/08/08)
A series of 4-(amido-biarylether)-quinolines was prepared as potential LXR agonists. Appropriate substitution with amide groups provided high affinity LXR ligands, some with excellent potency and efficacy in functional assays of LXR activity. Novel amide