854895-24-2Relevant academic research and scientific papers
Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif
Bakunov, Stanislav A.,Bakunova, Svetlana M.,Bridges, Arlene S.,Wenzler, Tanja,Barszcz, Todd,Werbovetz, Karl A.,Brun, Reto,Tidwell, Richard R.
supporting information; experimental part, p. 5763 - 5767 (2010/02/28)
Forty-eight cationically substituted pentamidine congeners possessing benzofuran rings were synthesized by a copper mediated heteroannulation of substituted o-iodophenols with phenyl acetylenes. Activities of compounds 1-48 against Trypanosoma brucei rhod
CATIONIC SUBSTITUTED BENZOFURANS AS ANTIMICROBIAL AGENTS
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Page/Page column 82-83, (2008/06/13)
A method of treating a Myobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
