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1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide, commonly referred to as BIPHEPHOS, is a chiral phosphine ligand that plays a pivotal role in organometallic chemistry. 1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide is distinguished by its diazaphospholidine ring and the presence of two 2,6-diisopropylphenyl groups, which provide significant steric hindrance and chiral characteristics. BIPHEPHOS is highly regarded for its capacity to facilitate a variety of asymmetric reactions, such as hydroformylation, hydrogenation, and cycloaddition, making it an indispensable asset in the realm of asymmetric synthesis for both academic and industrial applications.
Used in Asymmetric Synthesis:
1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide is used as a chiral phosphine ligand for promoting asymmetric reactions. Its unique structure and steric properties enable the selective formation of enantiomerically pure compounds, which is crucial for the production of biologically active molecules and pharmaceuticals.
Used in Organometallic Chemistry:
In the field of organometallic chemistry, 1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide is used as a catalyst to enhance the efficiency and selectivity of various reactions. Its ability to stabilize transition metal complexes contributes to the success of catalytic processes, such as hydroformylation, where it aids in the production of aldehydes with high enantioselectivity.
Used in Pharmaceutical Industry:
1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide is used as a key component in the synthesis of chiral pharmaceuticals. The demand for enantiomerically pure drugs is increasing due to their superior efficacy and reduced side effects compared to their racemic counterparts. BIPHEPHOS plays a crucial role in ensuring the production of these high-quality pharmaceuticals.
Used in Academic Research:
In academic research, 1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide is used as a valuable tool for studying asymmetric reactions and developing new catalytic systems. Its unique properties allow researchers to explore novel reaction mechanisms and improve the understanding of stereoselective processes.
Used in Industrial Research and Development:
1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide is utilized in industrial research and development for the optimization of asymmetric synthetic routes and the scale-up of chemical processes. Its application in the production of chiral compounds ensures the efficient manufacturing of high-quality products for various industries, including pharmaceuticals, agrochemicals, and fine chemicals.

854929-36-5

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854929-36-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 854929-36-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,4,9,2 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 854929-36:
(8*8)+(7*5)+(6*4)+(5*9)+(4*2)+(3*9)+(2*3)+(1*6)=215
215 % 10 = 5
So 854929-36-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H39N2OP/c1-17(2)21-11-9-12-22(18(3)4)25(21)27-15-16-28(30(27)29)26-23(19(5)6)13-10-14-24(26)20(7)8/h9-14,17-20,30H,15-16H2,1-8H3

854929-36-5 Well-known Company Product Price

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  • TCI America

  • (B3479)  1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide  >98.0%(N)

  • 854929-36-5

  • 200mg

  • 490.00CNY

  • Detail

  • TCI America

  • (B3479)  1,3-Bis(2,6-diisopropylphenyl)-1,3,2-diazaphospholidine 2-Oxide  >98.0%(N)

  • 854929-36-5

  • 1g

  • 1,490.00CNY

  • Detail

  • Aldrich

  • (708275)  1,3-Bis-(2,6-diisopropylphenyl)-[1,3,2]diazaphospholidine2-oxide  97%

  • 854929-36-5

  • 708275-250MG

  • 475.02CNY

  • Detail

  • Aldrich

  • (708275)  1,3-Bis-(2,6-diisopropylphenyl)-[1,3,2]diazaphospholidine2-oxide  97%

  • 854929-36-5

  • 708275-1G

  • 1,415.70CNY

  • Detail

854929-36-5Downstream Products

854929-36-5Relevant academic research and scientific papers

Palladium-catalyzed Suzuki couplings using a novel diaminophosphine oxide as ligand

Mai, Wen Peng,Wang, Hui Hui,Yuan, Jin Wei,Yang, Liang Ru,Li, Zhi Cheng

scheme or table, p. 521 - 524 (2012/06/16)

A novel diaminophosphine oxide was synthesized and applied as ligand in palladium-catalyzed Suzuki couplings reaction of aryl bromides and chlorides. The coupling reaction proceeded smoothly at mild conditions using 2 mol% Pd 2(dba)3 in the presence of tBuOK.

Modular diamino- and dioxophosphine oxides and chlorides as ligands for transition-metal-catalyzed C-C and C-N couplings with aryl chlorides

Ackermann, Lutz,Born, Robert

, p. 2444 - 2447 (2007/10/03)

(Chemical Equation Presented) Air-stable diamino- and dioxophosphine oxides were used as ligands in palladium-catalyzed Suzuki reactions of aryl chlorides. Additionally, a diaminophosphine chloride was applied to palladium- and nickel-catalyzed C-C and C-N bond-forming reactions.

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