855249-35-3Relevant academic research and scientific papers
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase
Bratton, Larry D.,Auerbach, Bruce,Choi, Chulho,Dillon, Lisa,Hanselman, Jeffrey C.,Larsen, Scott D.,Lu, Gina,Olsen, Karl,Pfefferkorn, Jeffrey A.,Robertson, Andrew,Sekerke, Catherine,Trivedi, Bharat K.,Unangst, Paul C.
, p. 5576 - 5589 (2007)
In an effort to identify hepatoselective inhibitors of HMG-CoA reductase, two series of pyrroles were synthesized and evaluated. Efforts were made to modify (3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxy
N-ALKYL PYRROLES AS HMG-COA REDUCTASE INHIBITORS
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Page/Page column 59; 168, (2010/02/12)
HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. Formula (I).
